And Clinically Tested
HYALURONIC ACID & MSM
Hyaluronic acid (HA) and MSM: The active ingredients in Play Again Now®
The hyaluronic acid (HA) used in Play Again Now is a result of microbial fermentation and is derived from plant-based sources. This high-molecular-weight HA plays a significant role throughout the entire body.
In healthy tissue, HA supports normal homeostasis and suppresses cell proliferation, angiogenesis, inflammation, and stimulates immunogenicity – the ability to provoke an immune response in the body. HA also lessens the pro-inflammatory mediators and pain-producing neuropeptides released by activated synovial cells.
HA is present in every tissue of the body – primarily concentrated in the synovial fluid which bathes joints, muscles, tendons, ligaments, eyes and skin. HA is also found in cartilage, blood vessels and throughout the extracellular matrix.
The viscoelastic nature of synovial fluid due to the content of hyaluronic acid that is present. Synovial fluid has many important functions including serving as a lubricant, shock absorber and a nutrient carrier. As we age, overuse or sustain injury, the concentration level of HA diminishes in synovial fluid. The high-molecular-weight HA found in Play Again Now can help replenish the declining levels in the synovial fluid.
Hyaluronic acid is a key component of healthy cartilage. HA and other nutrients are delivered to the cartilage via synovial fluid – there are no blood vessels connected to cartilage. Higher HA concentration in synovial fluid supports cartilage health.
Hyaluronic acid is found in the entire extracellular matrix (ECM). All nutrients and metabolic waste are transported throughout the ECM – from cell to cell – by HA, locking moisture in and penetrating every cell of the body.
Additionally, HA plays a significant role in the fascia. At the junction between the deep fascia and the muscle, HA provides a lubricating layer which, like hydraulic fluid, allows smooth gliding between the fascia and the muscle it envelopes and protects.
MSM is an abbreviation of methylsulfonylmethane, an organic form of sulfur. It is the form in which sulfur appears in nature in all living organisms, and in which it is biologically active. MSM is an odorless, white, crystalline powder that is highly soluble in hot water and in a wide range of organic solvents. Biologically-active sulfur has been shown to possess preventive and therapeutic properties.
MSM is a naturally-occurring nutrient providing the body with essential sulfur and methyl groups used in healing and repair processes. MSM is often used by professional and amateur athletes alike for effective nutritional support of athletic performance and recovery from soft tissue and joint overuse or injury. MSM can safely be taken over the long term with no documented toxicity. As a result, athletes can achieve improved performance, address soreness, and experience soft tissue support without harmful side effects.
After soft tissue injuries, including the micro-tears in muscle that occur after rigorous training or competition, connective tissue requires rest and repair. Sulfur is one of the key requirements for connective tissue integrity and subsequent recovery. MSM provides a rich source of bioavailable sulfur to support connective tissue regeneration. MSM supplementation can help speed recovery for the active athlete at risk for overuse and injury.
For a clinical look at Play Again Now, read our published data.