Clinically Proven Test Results You Can Feel

Hyaluronic acid (HA) and MSM: The active ingredients in Play Again® Now

The hyaluronic acid (HA) used in Play Again Now is a result of microbial fermentation and is derived from plant-based sources. This high-molecular-weight HA plays a significant role throughout the entire body.

In healthy tissue, HA supports normal homeostasis and suppresses cell proliferation, angiogenesis, inflammation, and stimulates immunogenicity – the ability to provoke an immune response in the body. HA also lessens the pro-inflammatory mediators and pain-producing neuropeptides released by activated synovial cells.

HA is present in every tissue of the body – primarily concentrated in the synovial fluid which bathes joints, muscles, tendons, ligaments, eyes and skin. HA is also found in cartilage, blood vessels and throughout the extracellular matrix.

The viscoelastic nature of synovial fluid due to the content of hyaluronic acid that is present. Synovial fluid has many important functions including serving as a lubricant, shock absorber and a nutrient carrier. As we age, overuse or sustain injury, the concentration level of HA diminishes in synovial fluid. The high-molecular-weight HA found in Play Again Now can help replenish the declining levels in the synovial fluid.

Hyaluronic acid is a key component of healthy cartilage. HA and other nutrients are delivered to the cartilage via synovial fluid – there are no blood vessels connected to cartilage. Higher HA concentration in synovial fluid supports cartilage health.

Methylsulfonylmethane (MSM)

MSM is an abbreviation of methylsulfonylmethane, an organic form of sulfur. It is the form in which sulfur appears in nature in all living organisms, and in which it is biologically active. MSM is an odorless, white, crystalline powder that is highly soluble in hot water and in a wide range of organic solvents. Biologically-active sulfur has been shown to possess preventive and therapeutic properties.

MSM is a naturally-occurring nutrient providing the body with essential sulfur and methyl groups used in healing and repair processes. MSM is often used by professional and amateur athletes alike for effective nutritional support of athletic performance and recovery from soft tissue and joint overuse or injury. MSM can safely be taken over the long term with no documented toxicity. As a result, athletes can achieve improved performance, address soreness, and experience soft tissue support without harmful side effects.

Continued clinical research behind Play Again Now’S anti-inflammatory supplements

The sports nutrition recovery solution with clinically-proven results

Viscos, LLC is dedicated to meeting and exceeding nutraceutical industry standards through continuing clinical research initiatives.

Viscos first implemented its research program with a randomized, double-blind placebo-controlled clinical study to establish the safety and efficacy of its formula. That study, “Oral Intake of a Liquid High-Molecular-Weight Hyaluronan Associated with Relief of Chronic Pain and Reduced Use of Pain Medication: Results of a Randomized, Placebo-Controlled Double-Blind Pilot Study,”* was published in the peer-reviewed Journal of Medicinal Food in January 2015. Results from the four-week pilot study included:

  • Decreased pain
  • Reduced use of pain medication
  • Improved sleep quality
  • Overall safety well within normal parameters

The next research initiative extended the four-week clinical study into a year-long open-label study to confirm continuing safety and efficacy at the one-year mark: “Evaluation of effects of consumption of Play Again on chronic pain and functionality: Results from a 1-year open-label clinical study.” The data showed a steady decrease in pain and use of medication throughout the one-year study. By the end of the one-year study, a highly significant reduction in chronic pain was seen in the study participants.

Subsequently, a direct extension from the previous 4-week and 1-year studies was conducted, in order to verify the effectiveness of the new Play Again Now® formulation with the addition of MSM. The many improvements in this open label study (“Evaluation of effects of consumption of Play Again Now® on chronic pain in humans: An open-label feasibility study”) reached statistical significance already at two weeks, and continued to improve at four weeks. Improvements went beyond simple pain reduction, and significantly altered physical functioning and quality of life.

Viscos is engaged in continuing research and has additional completed study data on file. For additional information, contact

*”Oral Intake of a Liquid High-Molecular-Weight Hyaluronan Associated with Relief of Chronic Pain and Reduced Use of Pain Medication: Results of a Randomized, Placebo-Controlled Double-Blind Pilot Study,” Gitte S. Jensen, Victoria L. Attridge, Miki R. Lenninger, and Kathleen F. Benson. Journal of Medicinal Food 18 (1) 2015, 95–101.

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